Nutritional Medicine Journal

The Nutritional Medicine Journal (NMJ) is a specialist peer-reviewed scientific publication related to the application of personalised dietary interventions, foods, dietary factors, and nutritional supplements in clinical practice.

Topics include clinical nutrition, personalised nutrition, lifestyle medicine, micronutrients, amino acids, fatty acids, phytochemicals, probiotics, prebiotics, and functional beverages and foods.

The aim of the NMJ is to provide health professionals with authoritative and scientifically accurate articles on topics in nutritional medicine. Narrative and systematic reviews (and meta-analysis), original research relevant to clinical nutrition, case reports that describe novel or interesting treatments, research letters, and hypothesis are considered for publication. All submitted articles undergo peer review by the Editors or the Editorial Board before acceptance for publication.

Articles

Sulforaphane, 3,3'-Diindolylmethane and Indole-3-Carbinol: A Review of Clinical Use and Efficacy

Sulforaphane (SFN), 3,3′-diindolylmethane (DIM) and indole-3-carbinol (I3C, a precursor of DIM) are compounds that are obtained through eating cruciferous vegetables, which have been shown in epidemiological studies to have health benefits. SFN and DIM have been shown to have antioxidant, anti-inflammatory and anti-cancer effects, as well as playing important roles in cellular detoxification of xenobiotics through their effects on nuclear factor-kappa B (NF-kB) and nuclear factor erythroid 2-related factor 2 (Nrf2). DIM and I3C have also been shown to affect oestrogen metabolism. In view of these properties, SFN, DIM and I3C have been studied in clinical trials and, although clinical research is still limited, promising results have been seen in a number of health conditions. Full Article

Elgar, K. (2022) Sulforaphane (SFN), 3,3′-diindolylmethane (DIM) and indole-3-carbinol (I3C): A Review of Clinical Use and Efficacy. Nutr. Med. Rev., Jun; 2 (2): xxx

Ashwagandha: A Review of Clinical Use and Efficacy

Ashwagandha has a long tradition of use in Ayurvedic medicine, and is best known as an adaptogen, a compound that can help increase our resistance to stress. Preclinical research has also shown ashwagandha to have anti-inflammatory, antimicrobial, antioxidant, antidiabetic, anti-tumour, anti-ageing and neuroprotective properties. Steroidal alkaloids and lactones, including withaferin A and withanolides, are thought to be some of the most active compounds of the herb. Clinical research in humans has shown ashwagandha to be safe and of benefit in a range of conditions, including stress/anxiety, athletic performance, cognition, diabetes, insomnia and male infertility. Ashwagandha is generally considered to be safe, with a few minor possible side-effects, although care should be taken alongside certain drugs. Full Article

Cite as: Elgar K. Ashwagandha: A Review of Clinical Use and Efficacy. Nutr Med Rev. 2021 Mar; 2 (2): xxx

Coenzyme Q10: A Review of Clinical Use and Efficacy

Coenzyme Q10 (CoQ10) plays an essential role in energy production as part of the mitochondrial electron transfer chain. It also has antioxidant functions and is important for gene regulation, especially of genes involved in cell signalling, metabolism, inflammation, transport and transcription control. Whilst we can obtain small amounts from our diet, most CoQ10 is synthesised in our bodies, which is why it is not considered to be a vitamin. Production declines with age and may also be impaired through illness and/or certain medications, making supplementation an interesting intervention. Although clinical research has been mixed in some indications, CoQ10 supplementation has been found to be a safe and effective intervention in a variety of conditions, including cardiometabolic disorders, fibromyalgia syndrome, migraine and male infertility. Full Article

Cite as (AMA): Elgar K. (2021) Coenzyme Q10: A Review of Clinical Use and Efficacy. Nutr Med Rev., 1 (1), xxx.

Curcumin: A Review of Clinical Use and Efficacy

Turmeric has a long tradition of use in Ayurvedic medicine for a variety of indications, including digestive and liver support, in mood-related disorders and inflammatory conditions. Modern research has confirmed anti-inflammatory, antioxidant, anti-microbial and anti-tumour activities of compounds isolated from turmeric, including curcumin and other curcuminoids. Curcumin has poor bioavailability and various formulations have therefore been developed to overcome this issue. Clinical trials have shown benefits of curcuminoids in a wide range of conditions, including cardiometabolic, inflammatory and mood disorders. Turmeric extracts have been found to be safe in humans with only mild adverse events being observed in clinical trials, mostly gastrointestinal disturbances, but due to its physiological actions, some drug interactions are possible. Full Article

 Cite as (AMA): Elgar K. Curcumin: A Review of Clinical Use and Efficacy. Nutr Med Rev. 2021 Jul 15; 1 (1): 1-20.

Magnesium: A Review of Clinical Use and Efficacy

Magnesium is a co-factor for more than 300 different enzymatic processes, and therefore plays a role in virtually every process in the cell, including cellular energy production, neuromuscular and cardiac function, maintaining ionic gradients, regulation of cell membrane receptors and DNA, RNA and protein synthesis. It is also an essential structural component for DNA and RNA on the cellular level, as well as in bones and teeth.

Whilst overt magnesium deficiency is rare, subclinical deficiency appears to be common, and increases the risk of many chronic conditions. Organic magnesium formulations, such as citrate, have been shown to be slightly better absorbed than inorganic ones, but many clinical trials have used inorganic formulations of magnesium, mostly oxide and chloride, and have shown benefits in a range of conditions, including cardiometabolic conditions, bone health, pain and constipation. Full Article

Cite as: Elgar K. Magnesium: A Review of Clinical Use and Efficacy. Nutr Med Rev. 2021 Dec; 1 (1): XXX